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Pro-Stat® Research & Studies

Pro-Stat® Effective in Maintaining Nitrogen Balance and May be Superior in Preserving Lean Body Mass (LBM): A Double Blind Crossover Study.
Nicholas P. Hays, PhD; Helen Kim, MS, RD; Amanda M. Wells MS, RD; Oumitana Kajkenova, MD; William J. Evans, PhD. Journal of the American Dietetic Association. 2009 June;Vol 109/No.6, 1082-1087.

Abstract 

Many elderly people have a low intake of dietary protein, yet their protein requirement may be higher than the current Recommended Dietary Allowance. High-quality protein supplements may be useful to enhance nitrogen retention and increase the availability of essential amino acids in elderly people. We compared the nitrogen balance of two protein supplements (Resource Beneprotein Instant Protein Powder, Nestlé HealthCare Nutrition, Minnetonka, MN, a whey protein concentrate; or Pro-Stat 101, Medical Nutrition USA, Englewood, NJ, a concentrated, fortified, collagen protein hydrolysate) varying in type but not amount of protein content using a crossover study design. The study consisted of two 15-day diet trials separated by a ≥1-week washout period. Nine healthy elderly women (age 71±1 years) were provided a eucaloric diet containing approximately the protein Recommended Dietary Allowance of 0.8 g/kg body weight/day. The supplements constituted about half of the total protein provided to each subject. Nitrogen balance responses were assessed over days 6 to 10 and days 11 to 14 of each trial. Measured nitrogen content of the foods indicated that subjects consumed 0.81±0.02 g protein/kg/day and 0.85±0.05 g/kg/day for the whey and fortified collagen protein trials, respectively. Body weight decreased (P=0.02) after consumption of the whey supplement, with no significant changes in body weight or composition resulting from the consumption of the collagen supplement. Nitrogen excretion was higher during the whey supplement trial than during the collagen trial (P=0.047). Therefore, a concentrated, fortified, hydrolyzed collagen protein supplement maintained nitrogen balance and preserved lean body mass during 15 days of consumption of a relatively low-protein diet.

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Pressure Ulcer Healing with a Concentrated, Fortified, Collagen Protein Hydrolysate Supplement: A Randomized Controlled Trial
Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ
Adv Skin Wound Care. 2006 Mar;19:92-6.

OBJECTIVE: To compare Pressure Ulcer Scale for Healing (PUSH) scores at 8 weeks in long-term-care residents with pressure ulcers who were given standard care plus a concentrated, fortified, collagen protein hydrolysate supplement vs. residents who were given standard care plus placebo.

DESIGN: Randomized, prospective, controlled, multicenter trial at 23 long-term-care facilities in 4 states.

SUBJECTS: A total of 89 residents with Stage II, III, or IV pressure ulcers were entered into the trial; 71 residents completed the study.

INTERVENTION: Residents were randomized to receive standard care plus a concentrated, fortified, collagen protein hydrolysate supplement (n = 56) or standard care plus placebo (n = 33) 3 times daily for 8 weeks. Wound healing was assessed biweekly using the PUSH tool, version 3.0. This tool categorizes pressure ulcers by surface area, exudate, and type of wound tissue.

PRIMARY OUTCOME MEASURE: Change in PUSH tool scores in each group at 8 weeks.

RESULTS: After 8 weeks of treatment, residents who received standard care plus the concentrated, fortified, collagen protein hydrolysate supplement had significantly better PUSH tool scores compared with those who received standard care plus placebo (3.55 ± 4.66 vs 3.22 ± 4.11, respectively; P < .05).

CONCLUSION: By week 8, PUSH tool scores-a measurement of pressure ulcer healing-showed approximately twice the rate of pressure ulcer healing in the treatment group compared with the control group. A concentrated, fortified, collagen protein hydrolysate supplement may be of benefit to residents of long-term-care facilities who have pressure ulcers.


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